How Potent is Nattokinase as Natural Blood Thinner And What Are the Risks?

As a fibrinolytic enzyme, nattokinase may help prevent clots and reduce stroke risks. Discover how it compares to prescription thinners along with safe dosage and who should not take natto supplements.

Nattokinase is a natural enzyme that is derived from the traditional Japanese food called natto. Natto is made from fermented soybeans and has been consumed in Japan for centuries due to its numerous health benefits. Nattokinase is known for its ability to thin the blood and prevent the formation of blood clots, making it an effective natural alternative to conventional blood thinners.

The history of nattokinase dates back to ancient Japan, where natto was first discovered. It is believed that natto was accidentally created when soybeans were left to ferment in straw. Over time, people realized that consuming natto had various health benefits, including improved cardiovascular health. The enzyme responsible for these benefits was later identified as nattokinase.

Blood thinners play a crucial role in preventing cardiovascular diseases such as heart attacks and strokes. These conditions are often caused by the formation of blood clots that block the flow of blood to vital organs. By thinning the blood, nattokinase helps to prevent the formation of these clots and reduce the risk of cardiovascular diseases.

Understanding the Mechanism of Action of Nattokinase

Nattokinase works by breaking down fibrin, a protein involved in blood clot formation. Fibrin forms a mesh-like structure that traps platelets and other blood cells, leading to the formation of clots. Nattokinase breaks down this fibrin mesh, preventing the formation of clots and improving blood flow.

Compared to other blood thinners such as warfarin and aspirin, nattokinase has several advantages. Firstly, it is a natural enzyme derived from food, making it safer and more easily tolerated by the body. Additionally, nattokinase has been shown to have a longer duration of action compared to conventional blood thinners, meaning that it remains active in the body for a longer period of time.

Clinical Studies on the Efficacy of Nattokinase

Numerous clinical studies have been conducted to evaluate the efficacy of nattokinase as a blood thinner. These studies have shown promising results, with nattokinase demonstrating the ability to effectively reduce blood clot formation and improve blood flow.

One study published in the Journal of Cardiovascular Pharmacology found that nattokinase significantly reduced blood clot formation in patients with deep vein thrombosis. Another study published in the Journal of Nutritional Science and Vitaminology showed that nattokinase improved blood flow and reduced blood pressure in individuals with hypertension.

When compared to other natural blood thinners such as garlic and fish oil, nattokinase has been found to be more effective in reducing blood clot formation. A study published in the Journal of Agricultural and Food Chemistry found that nattokinase had a stronger fibrinolytic activity compared to garlic and fish oil.

How Potent is Nattokinase Compared to Conventional Blood Thinners?

When comparing the potency of nattokinase with conventional blood thinners such as warfarin and aspirin, it is important to consider both the benefits and disadvantages of each option.

Warfarin is a commonly prescribed blood thinner that works by inhibiting the production of certain clotting factors in the liver. While warfarin is effective in preventing blood clots, it requires regular monitoring of blood levels and can have potentially dangerous interactions with other medications and foods. Nattokinase, on the other hand, is a natural enzyme that is generally well-tolerated and does not require regular monitoring.

Aspirin is another commonly used blood thinner that works by inhibiting platelet aggregation. While aspirin is readily available over-the-counter and has been shown to reduce the risk of heart attacks and strokes, it can also cause gastrointestinal bleeding and other side effects. Nattokinase, on the other hand, has been shown to have a longer duration of action and a lower risk of side effects compared to aspirin.

Potential Benefits of Nattokinase in Preventing Cardiovascular Diseases

The potential benefits of nattokinase in preventing cardiovascular diseases extend beyond its ability to thin the blood. Nattokinase has been shown to have anti-inflammatory properties, which can help reduce inflammation in the blood vessels and improve overall cardiovascular health.

In addition, nattokinase has been found to have antioxidant properties, which can help protect against oxidative stress and reduce the risk of atherosclerosis. A study published in the Journal of Agricultural and Food Chemistry found that nattokinase had a strong antioxidant activity, which may contribute to its cardiovascular benefits.

Furthermore, nattokinase has been shown to improve endothelial function, which is important for maintaining healthy blood vessels. Endothelial dysfunction is a common precursor to cardiovascular diseases, and improving endothelial function can help reduce the risk of heart attacks and strokes.

Risks and Side Effects of Nattokinase

While nattokinase is generally considered safe for most people, there are some potential side effects and risks associated with its use. Some individuals may experience mild gastrointestinal symptoms such as nausea or diarrhea when taking nattokinase. These side effects are usually temporary and resolve on their own.

There is also a potential risk of excessive bleeding when taking nattokinase, especially in individuals who are already taking other blood thinners or have a bleeding disorder. It is important to consult with a healthcare professional before starting nattokinase or any other blood thinner to ensure that it is safe for you.

Precautions and Contraindications for Nattokinase Use

There are certain precautions and contraindications for the use of nattokinase. Individuals who are taking other blood thinners such as warfarin or aspirin should exercise caution when using nattokinase, as it may increase the risk of bleeding. It is important to consult with a healthcare professional before starting nattokinase if you are already taking other medications.

Pregnant and breastfeeding women should also avoid using nattokinase, as there is limited research on its safety in these populations. Additionally, individuals with bleeding disorders or those who are scheduled for surgery should avoid using nattokinase.

Interactions of Nattokinase with other Medications

Nattokinase may interact with certain medications, including other blood thinners and antiplatelet drugs. It is important to inform your healthcare professional about all the medications you are taking before starting nattokinase to avoid potential interactions.

To minimize the risk of interactions, it is recommended to take nattokinase at least two hours before or after taking other medications. This allows for proper absorption and reduces the likelihood of interactions.

Dosage and Administration of Nattokinase

The recommended dosage of nattokinase varies depending on the individual and the specific health condition being treated. It is important to follow the instructions provided by the manufacturer or consult with a healthcare professional for personalized dosing recommendations.

Nattokinase is typically taken orally in capsule form. It is important to take it with a full glass of water to ensure proper absorption. It is also recommended to take nattokinase on an empty stomach, at least two hours before or after meals, for optimal effectiveness.

Conclusion: Is Nattokinase a Safe and Effective Natural Blood Thinner?

In conclusion, nattokinase is a natural enzyme derived from fermented soybeans that has been shown to effectively thin the blood and prevent the formation of blood clots. It has numerous potential benefits in preventing cardiovascular diseases, including its ability to improve blood flow, reduce inflammation, and protect against oxidative stress.

While nattokinase is generally considered safe for most people, it is important to exercise caution and consult with a healthcare professional before starting nattokinase or any other blood thinner. It may interact with certain medications and can increase the risk of bleeding in some individuals.

Overall, nattokinase offers a natural alternative to conventional blood thinners with potentially fewer side effects and a longer duration of action. However, it is important to weigh the benefits and risks and make an informed decision in consultation with a healthcare professional.